Search peptides — top sellers first
Search peptides — top sellers first
Search peptides — top sellers first
KSM-66 ashwagandha root extract for stress response, sleep quality, and exercise recovery.
Secure, encrypted checkout
Ashwagandha · mg
Frequently bought together
Researchers usually add these to complete the protocol.
Zinc Bisglycinate · mg
Popular · Foundation
Vitamin C · mg
Foundation
L-Theanine · mg
Recovery
Certificate of analysis
We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.
Vantage Analytical
Independent analytical lab
Certificate of Analysis
RESULT · PASS
Analytical results
HPLC Chromatogram
Purity
Know your compound
Ashwagandha is a shrub root used in traditional Indian practice. Its steroidal lactones, called withanolides, are considered the main active constituents, which is why extracts are standardized to them rather than sold by raw weight. It is studied for its effect on the hypothalamic-pituitary-adrenal axis, the body's system for releasing cortisol, the primary stress hormone. KSM-66 is a root-only extract, and root differs meaningfully from leaf in composition.
In one 60-day trial, adults taking the extract showed lower serum cortisol and lower perceived-stress scores than placebo. Among botanicals, this is one of the better-evidenced, with multiple randomized trials on perceived stress and cortisol. Most run 8 to 12 weeks, a meaningful share are industry-funded, and they use varying extracts — read the effect sizes with that in mind.
For research use only — not for human or veterinary use.
The research
The published findings behind this compound — the headline numbers, in plain terms, each cited to source. Preclinical results are directional (animal / in-vitro) and shown for context, not as therapeutic claims.
Published research on the reference compound class. Provided for scientific context only — not a claim about the product supplied.
In a 60-day randomized trial of chronically stressed adults, those taking a full-spectrum root extract had meaningfully lower serum cortisol than the placebo group.
Serum cortisol at 60 days; double-blind RCT.
In the same 60-day trial, stressed adults rated their perceived stress lower than the placebo group on a validated stress scale.
Self-rated perceived-stress scale at 60 days.
In a separate 60-day placebo-controlled trial, adults reporting stress showed gradual declines in both self-rated stress and morning cortisol versus placebo across the study.
Relative self-rated stress and morning cortisol; magnitude varied.
A 2021 review of controlled trials reports consistent directional improvements across stress, anxiety and sleep measures, though extracts and study lengths varied.
Directional summary across trials; no single pooled figure.
Mechanism
Ashwagandha is studied to act through three distinct routes tied to the body's stress signalling.
Withanolides are studied for their effect on the hypothalamic-pituitary-adrenal axis, the loop that governs cortisol release during stress.
Preclinical work suggests components may interact with GABA-related signalling, the calming pathway relevant to sleep and restfulness.
It is classed as an adaptogen, studied for helping the body maintain a balanced response to everyday physical and mental load.
For research use only. Mechanisms described reflect published preclinical and clinical literature.
The process
Synthesized
Produced under controlled manufacturing with documented, repeatable processes.
HPLC purity
An independent lab reports the exact purity of every lot — a number, never a 'passes'.
Mass-spec identity
Molecular weight confirms the exact sequence is what the label says.
COA published
The certificate is posted to the open library, by lot, before the vial ships.
Best sellers
FAQ
Common questions about Ashwagandha
The COA guarantee
Have any lot independently re-tested. If the results don't match the published certificate, we refund the order in full — no returns, no questions.
Order with coverThird-party tested
An independent, accredited lab — no commercial interest in the result.
A COA on every lot
A lot-specific certificate ships with each vial, archived by batch.
Test it yourself → refund
Re-test any batch at any lab. A mismatch is a full refund.
