Search peptides — top sellers first
Search peptides — top sellers first
Search peptides — top sellers first
Methylfolate and methylcobalamin B-complex for cellular energy, methylation, and homocysteine metabolism.
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Methylated B-Complex · mg
Frequently bought together
Researchers usually add these to complete the protocol.
Zinc Bisglycinate · mg
Popular · Foundation
Vitamin C · mg
Foundation
L-Theanine · mg
Recovery
Certificate of analysis
We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.
Vantage Analytical
Independent analytical lab
Certificate of Analysis
RESULT · PASS
Analytical results
HPLC Chromatogram
Purity
Know your compound
B vitamins are cofactors your enzymes need for two big jobs: turning food into usable energy and running the methylation cycle. Methylation is the reaction network that builds neurotransmitters, maintains DNA, and recycles homocysteine, an amino acid your body converts back into methionine. Several B vitamins arrive from food in an inactive form and need enzymatic conversion first, folic acid to 5-MTHF and cyanocobalamin to methylcobalamin. This complex supplies those converted forms directly.
A large fraction of people carry reduced-activity MTHFR gene variants that slow the conversion of folic acid to its active form. That is the reason methylated forms get so much attention, though whether they outperform standard forms in people without those variants is less settled than the marketing suggests. Most of the settled biochemistry comes from deficiency research, where the consequences of missing each cofactor are well characterized.
For research use only — not for human or veterinary use.
The research
The published findings behind this compound — the headline numbers, in plain terms, each cited to source. Preclinical results are directional (animal / in-vitro) and shown for context, not as therapeutic claims.
Published research on the reference compound class. Provided for scientific context only — not a claim about the product supplied.
Across human studies, people with better folate, B12 and B6 status tended to have lower plasma homocysteine — a directional inverse relationship, with the size varying by population and baseline status.
Directional relationship from a review; heights are illustrative, not measured effect sizes.
A review of ageing notes that B12 absorption and folate status commonly decline as people get older, so older adults are more likely to sit at the marginal end — though the magnitude varies from person to person.
Younger adults
absorption typically adequate
Midlife
status begins to slip in some
Older age
reduced B12 absorption, marginal folate more common
Direction of change from a narrative review; timing and size vary by individual.
A mechanism review describes how all eight B vitamins act as cofactors in brain energy and neurotransmitter pathways, with the clearest benefit seen where dietary intake is inadequate rather than already replete.
B vitamins with reviewed cofactor roles in the brain
Narrative mechanism review; benefit most evident where intake is inadequate.
Mechanism
The eight B vitamins are studied to act through three distinct biochemical routes in the body.
Several B vitamins are involved as cofactors in the enzyme reactions that release energy from carbohydrate, fat and protein.
Active folate and methylcobalamin participate directly in the one-carbon reactions that build neurotransmitters and maintain DNA.
Folate, B12 and B6 contribute to the pathways that convert homocysteine back into methionine.
For research use only. Mechanisms described reflect published preclinical and clinical literature.
The process
Synthesized
Produced under controlled manufacturing with documented, repeatable processes.
HPLC purity
An independent lab reports the exact purity of every lot — a number, never a 'passes'.
Mass-spec identity
Molecular weight confirms the exact sequence is what the label says.
COA published
The certificate is posted to the open library, by lot, before the vial ships.
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FAQ
Common questions about Methylated B-Complex
The COA guarantee
Have any lot independently re-tested. If the results don't match the published certificate, we refund the order in full — no returns, no questions.
Order with coverThird-party tested
An independent, accredited lab — no commercial interest in the result.
A COA on every lot
A lot-specific certificate ships with each vial, archived by batch.
Test it yourself → refund
Re-test any batch at any lab. A mismatch is a full refund.
